AT-101 acts as anti-proliferative and hormone suppressive agent in mouse pituitary corticotroph tumor cells


YUREKLI B. S. , KARACA B., Kisim A., Bozkurt E., Atmaca H., ÇETİNKALP Ş. , ...More

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol.41, no.2, pp.233-240, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1007/s40618-017-0733-8
  • Title of Journal : JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Page Numbers: pp.233-240
  • Keywords: AT-101, Cytotoxicity, Apoptosis, AtT20, ACTH, CUSHINGS-DISEASE, ANTERIOR-PITUITARY, RETINOIC ACID, CANCER CELLS, BCL-2 FAMILY, IN-VIVO, APOPTOSIS, GOSSYPOL, EXPRESSION, DRUGS

Abstract

Purpose Gossypol, a naturally occurring compound in cottonseeds, has anticancer effects against several tumor cell lines. It has been extensively studied in clinical trials and is well tolerated with a favorable safety profile. AT-101, a derivative of R (-)-gossypol, binds to Bcl-2 family proteins and induces apoptosis in vitro. Although transsphenoidal surgical excision of the pituitary corticotroph adenoma is the gold standard of care, it is not successful all the time. Medical therapy for Cushing's disease still remains a challenge for the clinicians. We aimed to investigate the cytotoxic and apoptotic effects of AT-101 in mouse pituitary corticotroph tumor AtT20 cells.