The Relationships between Serum sTWEAK, FGF-23 Levels, and Carotid Atherosclerosis in Renal Transplant Patients


GUNGOR O., KISMALI E. , Sisman A. R. , KIRCELLI F., Carrero J. J. , TATAR E., ...More

RENAL FAILURE, vol.35, no.1, pp.77-81, 2013 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.3109/0886022x.2012.734890
  • Title of Journal : RENAL FAILURE
  • Page Numbers: pp.77-81
  • Keywords: sTWEAK, FGF-23, atherosclerosis, renal transplantation, INTIMA-MEDIA THICKNESS, CHRONIC KIDNEY-DISEASE, GROWTH-FACTOR 23, HEMODIALYSIS-PATIENTS, MULTIFUNCTIONAL CYTOKINE, CARDIOVASCULAR-DISEASE, WEAK INDUCER, TWEAK, ARTERY, PROLIFERATION

Abstract

Background: Cardiovascular disease is the main cause of mortality after renal transplantation. Soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) and fibroblast growth factor-23 (FGF-23) are two novel molecules that have been associated with atherosclerosis in different populations. In this cross-sectional study, we investigated the associations between sTWEAK, FGF-23, and carotid artery intima-media thickness (CA-IMT) in renal transplant patients. Methods: A total of 117 renal transplant patients were studied. CA-IMT was determined by B-mode Doppler ultrasonography. Serum sTWEAK and FGF-23 were measured by a commercially available enzyme-linked immunosorbent assay (ELISA). Results: Mean age was 39.6 +/- 9.6 years and 51% of the patients were male. Mean sTWEAK level was 595 +/- 225 pg/mL (158-1140), FGF-23 level was 92 +/- 123 RU/mL (9.6-1006), and CA-IMT level was 0.62 +/- 0.11 mm (0.40-0.98). sTWEAK level was positively correlated with CA-IMT. There was no association between sTWEAK and FGF-23 levels. FGF-23 was also associated with CA-IMT. In adjusted models using linear regression analysis, only age and serum TWEAK levels were predictors for CA-IMT. Conclusion: There is a positive correlation between CA-IMT and sTWEAK, but not with FGF-23 levels in renal transplant patients.