A successful desensitization protocol for horse-derived antithymocyte globulin in severe aplastic anemia


Demir E. , Cigerci G., Karadaş N. , Gülen F. , Tanac R., Yılmaz D.

PEDIATRIC ALLERGY AND IMMUNOLOGY, vol.26, no.2, pp.168-172, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 2
  • Publication Date: 2015
  • Doi Number: 10.1111/pai.12335
  • Title of Journal : PEDIATRIC ALLERGY AND IMMUNOLOGY
  • Page Numbers: pp.168-172

Abstract

BackgroundHorse antithymocyte globulin (h-ATG) (ATGAM((R))) is the first choice of treatment in very severe patients with aplastic anemia who do not have any HLA matched sibling donor. h-ATG is a heterologous serum that may cause anaphylaxis. Alternative treatment strategies must be planned in case of hypersensitivity. Desensitization must be considered in patients without an alternative treatment of choice. We aimed to present the h-ATG desensitization protocol and consider its effectiveness in patients with aplastic anemia who are hypersensitized with h-ATG and do not have an alternative treatment of choice.