Multiple-drug therapy is common in current clinical practice. Because of this, people have been ready to embrace simplistic approaches to cold treatment, such as vitamin C and zinc. Ascorbic acid (vitamin C) is mostly administrated together with cough-cold drugs. The aim of this study was to investigate the effect of cough-cold drugs on the uptake of ascorbic acid using Tc-99m-ascorbic acid (Tc-99m-AA) in male albino Wistar rats. Ascorbic acid was labeled with Tc-99m and the distribution of Tc-99m-AA was investigated. The uptake of Tc-99m-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV). In some organs (apart from kidneys, intestinal system, and stomach) the uptake of Tc-99m-AA was not significantly affected by the administration of Tc-99m with CPR or Tc-99m with APAP at 120 min. On the other hand, there was significant difference in the uptake of Tc-99m-AA between groups I and III. The administration of Tc-99m-AA with PPA in rats caused an increase of the uptake of Tc-99m-AA at 120 min in the investigated organs compared to the administration of Tc-99m-AA alone. The present data show that vitamin C might be more effective for the treatment of common cold when coad-ministered with PPA compared to with CPR, with APAP, or alone.