pH-Responsive Polymersome Microparticles as Smart Cyclodextrin-Releasing Agents


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Puglısı A., Bayır E. , Timur S. , Yağcı Y.

BIOMACROMOLECULES, cilt.20, ss.4001-4007, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 10
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1021/acs.biomac.9b01083
  • Dergi Adı: BIOMACROMOLECULES
  • Sayfa Sayıları: ss.4001-4007

Özet

Cyclodextrins (CDs) are increasingly drawing attention as potential therapeutic tools in the treatment of cholesterol-associated diseases. However, bioavailability and delivery of CDs in the monomeric form still remain challenging. CD-based macromolecular systems seem to display a promising capacity in overcoming some of these limitations. Therefore, smart, stimuli-responsive nanosystems are currently being investigated in order to provide improved CD-releasing agents. Herein, we present a novel class of CD based polymersome microparticles (CD-PMs) designed for potential therapeutic use. A new synthetic route to obtain a CD-appended, pH-sensitive polymer that self-assembles into a stable polymersome microparticle is reported. Through an easy-to-use approach, a benzoic imine bond is incorporated into a poly(e-caprolactone) backbone and employed as a building block in the construction of the nanoarchitecture. The CD-PMs show cellular uptake representing a promising potential therapeutic tool in the treatment of cholesterol-associated conditions such as neurodegenerative diseases.