Oxidative stress impairs endothelial nitric oxide levels in Behcets' disease


Onur E., KABAROĞLU C. , Inanir I., Var A., Guvenc Y., Gunay O., ...Daha Fazla

CUTANEOUS AND OCULAR TOXICOLOGY, cilt.30, ss.217-220, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/15569527.2011.554480
  • Dergi Adı: CUTANEOUS AND OCULAR TOXICOLOGY
  • Sayfa Sayıları: ss.217-220

Özet

Background: Behcet's disease (BD) is an inflammatory vasculitis. Endogenous nitric oxide (NO), produced by endothelial cells, has pleiotropic effects such as vasodilatator, antiplatelet, antiproliferative. Reactive oxygen species (ROS) are produced at sites of endothelial inflammation. ROS target polyunsaturated lipids, which results in malondialdehyde (MDA) production.