Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events

DE KLEIJN, Dominique; MOLL, Frans; HELLINGS, Willem; Ozsarlak-Sozer, GÖNEN; DE BRUIN, Peter; DOEVENDANS, Pieter; VINK, Aryan; CATANZARITI, Louise; SCHONEVELD, Arjan; ALGRA, Ale; Daemen, Mat; BIESSEN, E.; de Jager, W.; ZHANG, Huoming; DE VRIES, Jean-Paul; Falk, Erling; LIM, Sai; VAN DER SPEK, Peter; SZE, Siu; PASTERKAMP, Gerard

doi:10.1161/atvbaha.109.194944

Local Atherosclerotic Plaques Are a Source of Prognostic Biomarkers for Adverse Cardiovascular Events

DE KLEIJN D. P. V. , MOLL F. L. , HELLINGS W. E. , Ozsarlak-Sozer G. , DE BRUIN P., DOEVENDANS P. A. , ...More

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, vol.30, no.3, pp.612-0, 2010 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 30 Issue: 3
Publication Date: 2010
Doi Number: 10.1161/atvbaha.109.194944
Title of Journal : ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Page Numbers: pp.612-0
Keywords: arterectomy, atherosclerosis, biomarker, plaque, PLASMA OSTEOPONTIN LEVELS, ACUTE CORONARY SYNDROMES, CAROTID-ARTERY STENOSIS, MYOCARDIAL-INFARCTION, RISK-FACTORS, DISEASE, MICE, RUPTURE

Abstract

Objective-Atherosclerotic cardiovascular disease is a major burden to health care. Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories.