Adjunctive low-dose doxycycline therapy effect on clinical parameters and gingival crevicular fluid tissue plasminogen activator levels in chronic periodontitis


EMINGIL G. , GURKAN A., Atilla G. , BERDELI A. , CMARCIK S.

INFLAMMATION RESEARCH, vol.55, no.12, pp.550-558, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 12
  • Publication Date: 2006
  • Doi Number: 10.1007/s00011-006-6074-2
  • Title of Journal : INFLAMMATION RESEARCH
  • Page Numbers: pp.550-558
  • Keywords: low-dose doxycycline, scaling and root planning, gingival crevicular fluid, GCF t-PA, adjunctive therapy, MATRIX-METALLOPROTEINASE INHIBITOR, COLLAGENASE ACTIVITY, HOST RESPONSE, EFFICACY, SYSTEM, LOCALIZATION

Abstract

Objective and design: The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a over 12-month period.