Adjunctive low-dose doxycycline therapy effect on clinical parameters and gingival crevicular fluid tissue plasminogen activator levels in chronic periodontitis

EMINGIL, GÜLNUR; GURKAN, A.; Atilla, FATMA; BERDELI, AFİG; CMARCIK, S.

doi:10.1007/s00011-006-6074-2

Adjunctive low-dose doxycycline therapy effect on clinical parameters and gingival crevicular fluid tissue plasminogen activator levels in chronic periodontitis

EMINGIL G. , GURKAN A., Atilla G. , BERDELI A. , CMARCIK S.

INFLAMMATION RESEARCH, vol.55, no.12, pp.550-558, 2006 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 55 Issue: 12
Publication Date: 2006
Doi Number: 10.1007/s00011-006-6074-2
Title of Journal : INFLAMMATION RESEARCH
Page Numbers: pp.550-558
Keywords: low-dose doxycycline, scaling and root planning, gingival crevicular fluid, GCF t-PA, adjunctive therapy, MATRIX-METALLOPROTEINASE INHIBITOR, COLLAGENASE ACTIVITY, HOST RESPONSE, EFFICACY, SYSTEM, LOCALIZATION

Abstract

Objective and design: The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a over 12-month period.