High degree of conservation in the hepatitis B virus core gene during the immune tolerant phase in perinatally acquired chronic hepatitis B virus infection

Bozkaya H., Akarca U. S. , Ayola B., Lok A.

JOURNAL OF HEPATOLOGY, vol.26, no.3, pp.508-516, 1997 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.1016/s0168-8278(97)80415-1
  • Title of Journal : JOURNAL OF HEPATOLOGY
  • Page Numbers: pp.508-516


Background: Mutations in the hepatitis B virus genome have been implicated in the persistence of hepatitis B virus infection and the pathogenesis of hepatitis B virus related liver disease, In view of the heterogeneity in published sequences, data from cross-sectional studies of unrelated subjects cannot differentiate true mutations from infections with variant sequences.