Effects of a Silenced Gene in Boolean Network Models


Haliki E. , Kazancı N.

Turkish Physical Society 33rd International Physics Congress, Muğla, Türkiye, 6 - 10 Eylül 2017, ss.5-6

  • Basıldığı Şehir: Muğla
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.5-6

Özet

Gene regulation and their regulatory networks are one of the most challenging research problems of computational biology and complexity sciences. Gene regulation is formed by indirect interaction between DNA segments which are protein coding genes to configure the expression level of one another. Prevention of expression of any genes in gene regulation at the levels of transcription or translation indicates the gene silencing event. The present study examined what types of results in gene silencing would bring about in the dynamics of Boolean genetic regulatory mechanisms. The analytical study was performed in gene expression variations of Boolean dynamics first, then the related numerical analysis was simulated in real networks in the literature.