Radiosynthesis and biodistribution of Tc-99m-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

Uyaroglu O., Demiroglu H., Topal G., Parlak Y., Gumuser F. G. , Turkoz E. U. , ...Daha Fazla

MEDICINAL CHEMISTRY RESEARCH, cilt.26, ss.3149-3157, 2017 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 26 Konu: 12
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1007/s00044-017-2009-4
  • Sayfa Sayıları: ss.3149-3157


The aim of this study was to prepare Tc-99m-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with Tc-99m and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 +/- 3.07% and remained constant at more than 93 +/- 0.1% even in serum for 240 min after radiolabeling. Tc-99m-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. Tc-99m-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.