Radiosynthesis and biodistribution of Tc-99m-Sulfamethoxazole: a novel molecule for in-vivo infection imaging


Uyaroglu O., Demiroglu H., Topal G., Parlak Y., Gumuser F. G. , Turkoz E. U. , ...More

MEDICINAL CHEMISTRY RESEARCH, vol.26, no.12, pp.3149-3157, 2017 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1007/s00044-017-2009-4
  • Title of Journal : MEDICINAL CHEMISTRY RESEARCH
  • Page Numbers: pp.3149-3157
  • Keywords: Sulfamethoxazole, Tc-99m, Infection imaging agent, S. aureus, FREEZE-DRIED KITS, ANTIMICROBIAL PEPTIDES, BACTERIAL-INFECTIONS, DETECTING SITES, QUALITY-CONTROL, TC-99M-CIPROFLOXACIN, AGENT, RADIOPHARMACEUTICALS, SCINTIGRAPHY, SULFONAMIDE

Abstract

The aim of this study was to prepare Tc-99m-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with Tc-99m and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 +/- 3.07% and remained constant at more than 93 +/- 0.1% even in serum for 240 min after radiolabeling. Tc-99m-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. Tc-99m-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.