Low-dose doxycycline inhibits hydrogen peroxide-induced oxidative stress, MMP-2 up-regulation and contractile dysfunction in human saphenous vein grafts


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Saeed M., Arun M. Z. , Guzeloglu M., Onursal C., Gökçe G. , Korkmaz C. G. , et al.

DRUG DESIGN DEVELOPMENT AND THERAPY, cilt.13, ss.1791-1801, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 13
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2147/dddt.s187842
  • Dergi Adı: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Sayfa Sayısı: ss.1791-1801

Özet

Background: Cardiopulmonary bypass (CPB) applied during coronary artery bypass grafting (CABG), promotes inflammation, generation of reactive oxygen species (ROS) and up-regulation of matrix metalloproteinases (MMPs). All these complications may lead to contractile dysfunction, restenosis and early graft failure, restricting long-term efficacy of bypass grafts. Low-dose doxycycline is a potent MMP inhibitor and ROS scavenger. In this study, we aimed to investigate the effects of doxycycline on ROS generation, MMP regulation and contractile dysfunction induced by H2O2 in human saphenous vein (HSV) grafts.