Thyroidal angiogenesis in zebrafish (Danio rerio) exposed to high perchlorate concentration


Ucuncu I. S. , Karayazi O., Isisag A.

AFRICAN JOURNAL OF BIOTECHNOLOGY, cilt.8, ss.1729-1733, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 8 Konu: 8
  • Basım Tarihi: 2009
  • Dergi Adı: AFRICAN JOURNAL OF BIOTECHNOLOGY
  • Sayfa Sayıları: ss.1729-1733

Özet

As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure.