Thyroidal angiogenesis in zebrafish (Danio rerio) exposed to high perchlorate concentration


Ucuncu I. S. , Karayazi O., Isisag A.

AFRICAN JOURNAL OF BIOTECHNOLOGY, vol.8, no.8, pp.1729-1733, 2009 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 8
  • Publication Date: 2009
  • Title of Journal : AFRICAN JOURNAL OF BIOTECHNOLOGY
  • Page Numbers: pp.1729-1733

Abstract

As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure.