Challenges in oral drug delivery and applications of lipid nanoparticles as potent oral drug carriers for managing cardiovascular risk factors.


Okur N. Ü. , Siafaka P. I. , Gökçe E. H.

Current pharmaceutical biotechnology, vol.22, pp.892-905, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22
  • Publication Date: 2021
  • Doi Number: 10.2174/1389201021666200804155535
  • Title of Journal : Current pharmaceutical biotechnology
  • Page Numbers: pp.892-905
  • Keywords: Oral drug delivery, bioavailability, nanoscience, lipid nanoparticles, nanotechnology, IN-VITRO, INTESTINAL-ABSORPTION, OLMESARTAN MEDOXOMIL, SYSTEM, BIOAVAILABILITY, CHITOSAN, VIVO, FORMULATION, DESIGN, OPTIMIZATION

Abstract

Background: The oral application of drugs is the most popular route through which the systemic effect can be achieved. Nevertheless, oral administration is limited by difficulties related to the physicochemical properties of the drug molecule, including low aqueous solubility, instability, low permeability, and rapid metabolism, all of which result in low and irregular oral bioavailability.