ETHANOL-INDUCED OXIDATIVE STRESS AND MEMBRANE INJURY IN RAT ERYTHROCYTES


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SOZMEN E. , TANYALCIN T., ONAT T., KUTAY F., ERLACIN S.

EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY, vol.32, no.10, pp.741-744, 1994 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 10
  • Publication Date: 1994
  • Doi Number: 10.1515/cclm.1994.32.10.741
  • Title of Journal : EUROPEAN JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.741-744

Abstract

The aim of this study was to observe membrane injury and to investigate the mechanism of antioxidant defence systems against acute ethanol toxicity. Erythrocyte superoxide dismutase and Na+, K+-ATPase activities were significantly decreased and catalase levels were significantly increased one hour after ethanol intoxication of male swiss albino rats. These data demonstrated that superoxide dismutase and catalase are susceptible to lipid peroxidation and that these enzymes protect tissues from free radicals. The possible mechanism involved in Na+ K+-ATPase and Ca2+-ATPase inhibition are discussed in relation to the development of ethanol toxicity and the role of lipid peroxidative processes.