Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis


GÜRKAN A. , EMINGIL G. , SAYGAN B. H. , Atilla G. , KÖSE T. , BAYLAS H., ...Daha Fazla

ARCHIVES OF ORAL BIOLOGY, cilt.54, ss.337-344, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Aim: Host response to periodontopathic microorganisms can be modulated by genetic factors. Accumulated evidence highlighted the role of renin-angiotensin system (RAS) in inflammatory response thus potential implication of this molecular system in the pathogenesis of periodontitis can be suggested. The present study investigated common genetic variants of molecules within the RAS family namely angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin 11 type 1 receptor (AT1R) in relation to generalized aggressive periodontitis (G-AgP).