An alternative evaluation method for swelling studies of bioadhesive tablet formulations


Baloglu E. , HIZARCIOGLU S. , KARAVANA H. A.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, cilt.9, ss.233-237, 2004 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 9 Konu: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1081/pdt-200031412
  • Dergi Adı: PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
  • Sayfa Sayıları: ss.233-237

Özet

A new and alternative evaluation method is preferred for swelling studies of bioadhesive tablet formulations. CIELAB color coordinates, related to visual color response, are used for the first time to follow the swelling state and to calculate the swelling volume. The results are evaluated statistically. A simple equation is given to explain the relation between the swelling volume change % and color difference for three different bioadhesive formulations. It was found that the estimated equation is in good agreement with observed swelling volume results.