Novel biologically active glycosides from the aerial parts of Cephalaria gazipashensis


Sarikahya N. , Kirmizigul S.

TURKISH JOURNAL OF CHEMISTRY, vol.36, no.2, pp.323-0, 2012 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.3906/kim-1105-32
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.323-0

Abstract

Two new triterpene glycosides, 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl olean-12-ene 28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (gazipashoside A, 1) and 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-xylopyranosyl-(1 -> 3)-alpha-L-rhamnopyranosyl-( 1 -> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-glucopyranosyl-(1 -> 6)-beta-D-glucopyranosyl ester (gazipashoside B, 2), were isolated together with 11 known compounds including 7 triterpene, 1 flavonoid, and 3 iridoidal metabolites from the aerial parts of Cephalaria gazipashensis (Dipsacaceae). The structures of all compounds were elucidated by extensive evaluation of the spectroscopic data (1D- and 2D-NMR, HRESI-MS), as well as chemical examinations. The antimicrobial effects of all pure compounds were tested against gram-positive and gram-negative bacteria. The results indicated that the 2 new triterpene glycosides might be acceptable as antimicrobial active agents.