Iron oxide nanoparticles coated with gelatin trough two-step desolvation method and characterized. SEM analyse showed that the nanoparticles are spherical and TEM image showed that the iron oxide nanoparticles encapsulated with gelatin. Also FTIR, TG and magnetization analyses exhibited that iron oxide nanoparticles encapsulated as well. Drug loading by adsorption studied under various conditions as different temperature, contact time and initial cisplatin concentration. Also, Langmuir, Freundlich and Dubinin-Raduskevich adsorption isotherm curves were constracted and constants were calculated. In vitro drug release was performed at pH 5 and 7.4 and hyperthermic drug release investigated at 42 degrees C and compared with non-hyperthermic drug release.