Can hyperbaric oxygenation decrease doxorubicin hepatotoxicity and improve regeneration in the injured liver?


Firat O. , KIRDOK O., Makay O. , Caliskan C. , Yilmaz F. , ILGEZDI S., ...Daha Fazla

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, cilt.16, ss.346-352, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 16 Konu: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s00534-009-0059-9
  • Dergi Adı: JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY
  • Sayfa Sayıları: ss.346-352

Özet

Portal vein embolization is used in the treatment of hepatocellular cancer, with the purpose of enhancing resectability. However, regeneration is restricted due to hepatocellular injury following chemotherapeutics (e.g. doxorubicin). The aim of this study was to investigate whether hyperbaric oxygenation (HBO) can alleviate the hepatotoxicity of chemotherapy and improve regeneration in the injured liver.