P53 protein expression in eccrine poroma and porocarcinoma


Akalin T. , Sen S. , YÜCETÜRK A., KANDİLOĞLU G.

AMERICAN JOURNAL OF DERMATOPATHOLOGY, cilt.23, ss.402-406, 2001 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 23 Konu: 5
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1097/00000372-200110000-00003
  • Dergi Adı: AMERICAN JOURNAL OF DERMATOPATHOLOGY
  • Sayfa Sayıları: ss.402-406

Özet

The role of p53 mutation has been shown in different human malignancies, including various skin cancers. In this study, we examined p53 protein expression in 25 eccrine poromas and 11 porocarcinomas by immunohistochemistry. P53 expression was observed in 88% (22 of 25) of eccrine poromas and 73% (8 of 11) of porocarcinomas. In eccrine poromas, percentage of cells reactive for p53 was less than 5% (low expresser) in 6 cases, 5 to 50% (moderate expresser) in 14 and greater than 50% (high expresser) in 2 cases. In terms of intensity, 13 cases showed weak staining, 8 moderate, and 1 case showed strong reactivity. On the other hand, 2 cases of porocarcinoma were low expresser, 2 were moderate and 4 were high expresser. All of the high expressers had also strong staining.