Mannose-binding lectin codon 54 gene polymorphism in relation to risk of nosocomial invasive fungal infection in preterm neonates in the neonatal intensive care unit


AYDEMİR C., ONAY H. , Oguz S. S. , Ozdemir T. R. , Erdeve O., Ozkinay F. F. , ...Daha Fazla

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.24, ss.1124-1127, 2011 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 9
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/14767058.2010.536865
  • Dergi Adı: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
  • Sayfa Sayıları: ss.1124-1127

Özet

Objective. Preterm neonates are susceptible to infection due to a combination of sub-optimal immunity and increased exposure to invasive organisms. Invasive fungal infections are associated with significant morbidity and mortality among preterm infants cared for in the neonatal intensive care unit (NICU). Mannose-binding lectin (MBL) is a component of the innate immune system, which may be especially important in the neonatal setting. The objective of this study was to investigate the presence of any association between MBL gene polymorphism and nosocomial invasive fungal infection in preterm neonates.