This article describes the background, legislations and new approaches in Turkey for control of drug use of drivers. In recent years, in parallel to the widespread use of illicit drugs, the number of drivers affected by drugs is also increasing. It is well established that alcohol impairs driving ability and increases the risk of accidents. New studies show the contribution of illicit drugs to fatal/nonfatal rood accidents. With the addition of social, economical and cultural factors, the traffic of drugs has resulted in an increased ratio of drugs of abuse and addiction in our country which is located in a crowded transition area (UNCLEAR). Drinking and driving have become less socially acceptable. Awareness has also grown about the impairment caused by other drugs.