Relation of Decreased Circulating Sortilin Levels With Unfavorable Metabolic Profiles in Subjects With Newly Diagnosed Type 2 Diabetes Mellitus


Demir I., Akan O. Y. , Guler A., Bozkaya G., Aslanipour B., Calan M.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, cilt.359, ss.8-16, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 359 Konu: 1
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.amjms.2019.10.003
  • Dergi Adı: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
  • Sayfa Sayıları: ss.8-16

Özet

Background: Sortilin, a pluripotent peptide hormone, plays a role in glucose and lipid metabolism. A link between sortilin and insulin sensitivity has been implicated. However, the clinical implications of this link remain elusive. Our aims were to investigate whether sortilin levels were altered in subjects with newly diagnosed type 2 diabetes mellitus (nT2DM) compared with subjects with normal glucose tolerance (NGT) and to determine whether a link exist between sortilin levels and metabolic parameters.