Risk factors for adverse events during collection of peripheral blood stem cells


DÖNMEZ A. , ARIK B., TOMBULOĞLU M. , ÇAĞIRGAN S.

TRANSFUSION AND APHERESIS SCIENCE, cilt.45, ss.13-16, 2011 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 45 Konu: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.transci.2011.06.015
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Sayfa Sayısı: ss.13-16

Özet

We retrospectively reviewed peripheral blood stem cell (PBSCs) collections following 528 mobilization cycles over a 10-year period. A total of 206 (13.1%) AEs occurred in association with the 1572 procedures. One hundred and ninety-one (12.15%) of the AEs were classified as clinical AEs and 15 (0.95%) were classified as apheresis instrument related AEs. The most common clinical AE was numbness of the lips, tongue, or extremities (161 procedures, 10.2%) related to the infusion of acid citrate dextrose-A (ACD). Multivariate analysis revealed high amounts of ACD/weight (odds ratio [OR] = 1.11, p = 0.009), high numbers of procedures (OR = 1.33, p < 0.001) and female gender (OR = 2.83, p < 0.001) as being significantly associated with clinical AEs. Female gender was shown to be the most important risk factor for clinical AEs. Females who have a significantly increased risk of AEs would benefit from prophylactic calcium before and/or during PBSC collection. (C) 2011 Elsevier Ltd. All rights reserved.