Characterization of the cellular response during apoptosis induction in cadmium-treated Hep G2 human hepatoma cells

Aydin H. H. , Celik H. , Deveci R. , Terzioglu E., KARAÇALI S., Mete N., ...Daha Fazla

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.95, ss.139-153, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 95 Konu: 2
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1385/bter:95:2:139
  • Sayfa Sayıları: ss.139-153


Cadmium is a toxic transition heavy metal of continuing occupational and environmental concern, with a wide variety of adverse effects on regulation of gene expression and cellular signal transduction pathways. Injury to cells by cadmium leads to a complex series of events that can culminate in the death of the cell. It has been reported that cadmium induces apoptosis in many cell lines. However, the morphological characteristics leading to apoptosis or subsequent regeneration in cells exposed to cadmium have not been clarified.