Assessment of effects of pinealectomy and exogenous melatonin administration on rat sciatic nerve suture repair: an electrophysiological, electron microscopic, and immunohistochemical study

TURGUT M., Uysal A. , PEHLIVAN M. , OKTEM G. , YURTSEVEN M.

ACTA NEUROCHIRURGICA, cilt.147, ss.67-77, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 147 Konu: 1
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00701-004-0426-x
  • Dergi Adı: ACTA NEUROCHIRURGICA
  • Sayfa Sayıları: ss.67-77

Özet

Background. Collagen sear formation at the cut end of a nerve, an important problem in clinical practice for neurosurgeons in peripheral nerve surgery, obstructs sprouting of axons into appropriate distal fascicles, and thereby limits nerve regeneration. Researchers attempt to control collagen accumulation in the formation of neuroma by various physical and chemical methods, but these have yielded only limited functional success. This is the first experimental study investigating the effects of melatonin (MLT) on nerve repair and neuronal regeneration in rat sciatic nerve suture repair.