The objective of the study is to investigate the effects of model calibration on seismic behaviour of a historical mosque which is one of the most significant Ottomon structures. Seismic analyses of calibrated and noncalibrated numeric models were carried out by using acceleration records of Kocaeli earthquake in 1999. In numerical analysis, existing crack zones on real structure was investigated in detail. As a result of analyses, maximum stresses and displacements of calibrated and noncalibrated numerical models were compared each other. Consequently, seismic behaviour and damage state of historical masonry Hafsa Sultan mosque was determined as more realistic in the event of a severe earthquake.