Determination of Adiponectin, Tumor Necrosis Factor-Alpha, and Adhesion Molecules in Alzheimer's Disease

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Savaş E. S. , Güler B., Saraç Z. F.

ERCIYES MEDICAL JOURNAL, vol.41, pp.170-174, 2019 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 41
  • Publication Date: 2019
  • Doi Number: 10.14744/etd.2019.60420
  • Title of Journal : ERCIYES MEDICAL JOURNAL
  • Page Numbers: pp.170-174


Objective: Though the data regarding the mechanisms behind neurodegeneration in addition to amyloid plaques and neurofibrillary tangles are not clear, there are emerging data for inflammation and microvascular changes to have contribution to the pathology of Alzheimer's disease (AD). The relationships between numerous biomarkers also need to be investigated. This study aimed to assess inflammatory marker tumor necrosis factor-alpha (TNF-alpha), adiponectin (a modulator of anti-inflammation), and potential microvascular markers for AD including both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in Turkish patients with AD and healthy elderly subjects, and the relationships among the variables in patients with AD.