Radiolabeling of codeine with I-131 and its biodistribution in rats


Enginar H., Unak P., Lambrecht F. , MUFTULER F. Z. B. , Medine E. I. , Yolcular S., ...Daha Fazla

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, cilt.280, ss.363-370, 2009 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 280 Konu: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1007/s10967-009-0528-2
  • Dergi Adı: JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
  • Sayfa Sayıları: ss.363-370

Özet

Codeine which was extracted from dry capsules of the opium poppy (Papaver somniferum) was purified by HPLC (High Performance Liquid Chromatography) and characterized by NMR (Nuclear Magnetic Resonance) and IR (Infrared) spectroscopy techniques. The purified compound was labeled with I-131 and biodistribution studies were performed in rats. Radioiodinated codeine distributed uniformly in the cerebellum, m.pons, striatum and hypothalamus while the other branch of brain and Stomach, urinary bladder, and small intestine uptakes were significantly higher than other tissues.