Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies

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Shirinzadeh H., EREN B., Gurer-Orhan H. , Suzen S., Ozden S.

MOLECULES, cilt.15, ss.2187-2202, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 15 Konu: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3390/molecules15042187
  • Dergi Adı: MOLECULES
  • Sayfa Sayıları: ss.2187-2202


The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H(2)O(2)-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.