A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers


GÖKÇE E. H. , KORKMAZ E., Tuncay-Tanriverdi S. , Dellera E., Sandri G., Bonferoni M. C. , ...More

INTERNATIONAL JOURNAL OF NANOMEDICINE, vol.7, pp.5109-5117, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2012
  • Doi Number: 10.2147/ijn.s34921
  • Title of Journal : INTERNATIONAL JOURNAL OF NANOMEDICINE
  • Page Numbers: pp.5109-5117

Abstract

Background: The effective delivery of coenzyme Q10 (Q10) to the skin has several benefits in therapy for different skin pathologies. However, the delivery of Q10 to deeper layers of skin is challenging due to low aqueous solubility of Q10. Liposomes and solid lipid nanoparticles (SLN) have many advantages to accomplish the requirements in topical drug delivery. This study aims to evaluate the influence of these nanosystems on the effective delivery of Q10 into the skin.