Circulatory antioxidant and oxidative stress markers are in correlation with demographics but not cognitive functions in multiple sclerosis patients

Naseri A., Forghani N., Sadigh-Eteghad S., Shanehbandi D., Asadi M., Nasiri E., ...More

MULTIPLE SCLEROSIS AND RELATED DISORDERS, vol.57, 2022 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 57
  • Publication Date: 2022
  • Doi Number: 10.1016/j.msard.2021.103432
  • Keywords: Oxidative stress, Multiple sclerosis, Cognition, Cognitive impairment, MACFIMS battery, CEREBROSPINAL-FLUID, MINIMAL ASSESSMENT, BIOMARKERS, DISABILITY, DAMAGE, IMPAIRMENT, VALIDITY


Background: Multiple sclerosis (MS) is the most common non-traumatic cause of disability in younger adults. MS can be presented with a wide range of symptoms such as cognitive impairment (CI). Oxidative stress (OXS) is a major basis of the pathogenesis of MS. There is a positive correlation between OXS factors and the progression of the disease in MS patients. There are limited studies regarding the role of OXS in MS-related CI. In this study, as an exploratory analysis, we assess the role of endogenous antioxidants and OXS factors in cognitive function, the severity of disability due to MS, and demographic findings in a sample of MS patients.