Radioiodination of Pimonidazole as a Novel Theranostic Hypoxia Probe


Inci I. D. , Tekin V., Yurt Kılçar A. , Kozguş Güldü Ö. , Medine E. İ. , Karatay K. B. , ...More

CURRENT RADIOPHARMACEUTICALS, vol.14, no.1, pp.46-50, 2021 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.2174/1874471013666200331114908
  • Title of Journal : CURRENT RADIOPHARMACEUTICALS
  • Page Numbers: pp.46-50
  • Keywords: Pimonidazole, tosylation, radioiodination, iodine-131, theranostic, hypoxia

Abstract

Background: Tumors are defined as abnormal tissue masses, and one of the most important factors leading to the growth of these abnormal tissue masses is Vascular Endothelial Growth Factor, which stimulates angiogenesis by releasing cells under hypoxic conditions. Hypoxia has a vital role in cancer therapy, thus it is important to monitor hypoxia. The hypoxia marker Pimonidazole (PIM) is a candidate biomarker of cancer aggressiveness.