Inhibition of renin-angiotensin system in experimental acute pancreatitis in rats: A new therapeutic target?


ORUÇ N. , Ozutemiz O. , NART D. , YÜCE G., Celik H. , Ilter T.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, vol.62, no.4, pp.353-360, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 62 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1016/j.etp.2009.05.001
  • Title of Journal : EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Page Numbers: pp.353-360

Abstract

Objective: Pancreatic renin-angiotensin system has been implied to play a role in the regulation of pancreatic functions and could be a new therapeutic target in acute pancreatitis. The aim of this study was to evaluate the therapeutic potential of angiotensin-converting-enzyme inhibition by captopril and angiotensin II type 1 receptor inhibition by L-158809 and losartan experimentally in acute pancreatitis.