Inhibition of renin-angiotensin system in experimental acute pancreatitis in rats: A new therapeutic target?


ORUÇ N. , Ozutemiz O. , NART D. , YÜCE G., Celik H. , Ilter T.

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, cilt.62, ss.353-360, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 62 Konu: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.etp.2009.05.001
  • Dergi Adı: EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
  • Sayfa Sayısı: ss.353-360

Özet

Objective: Pancreatic renin-angiotensin system has been implied to play a role in the regulation of pancreatic functions and could be a new therapeutic target in acute pancreatitis. The aim of this study was to evaluate the therapeutic potential of angiotensin-converting-enzyme inhibition by captopril and angiotensin II type 1 receptor inhibition by L-158809 and losartan experimentally in acute pancreatitis.