Giant cell hepatitis and autoimmune hemolytic anemia after chickenpox

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BARAN M., OZGENC F., BERK O., GOKCE D., Kavakli K. , YILMAZ F. , ...Daha Fazla

TURKISH JOURNAL OF GASTROENTEROLOGY, cilt.21, ss.448-451, 2010 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.4318/tjg.2010.0135
  • Sayfa Sayıları: ss.448-451


Autoimmune hemolytic anemia with giant cell hepatitis is a distinct entity in children. It is usually fatal with progressive liver disease. Immunosuppressive treatment with conventional drugs offers some response; however, it is usually only temporary. Alternative therapeutic options with monoclonals have been reported with promising remission of the disease. We report a case with autoimmune hemolytic anemia+giant cell hepatitis after varicella infection. She was resistant to standard immunosuppressive combinations, and rescue therapy with rituximab was used. Remission was not achieved with the drug and the child died with septic complication.