Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin


ŞENYİĞİT T., SONVİCO F., BARBİERİ S., Ozer O. , SANTİ P., COLOMBO P.

JOURNAL OF CONTROLLED RELEASE, vol.142, no.3, pp.368-373, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 142 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jconrel.2009.11.013
  • Title of Journal : JOURNAL OF CONTROLLED RELEASE
  • Page Numbers: pp.368-373

Abstract

In this study, clobetasol-17-propionate (CP) loaded lecithin/chitosan nanoparticles were studied with special attention to the transport of the active agent across the skin in vitro. Nanoparticles were characterized by measuring particle size, zeta potential, polydispersity index and encapsulation efficiency. The morphology of nanoparticles was evaluated by transmission electron microscopy.