Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin


ŞENYİĞİT T., SONVİCO F., BARBİERİ S., Ozer O. , SANTİ P., COLOMBO P.

JOURNAL OF CONTROLLED RELEASE, cilt.142, ss.368-373, 2010 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 142 Konu: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.jconrel.2009.11.013
  • Dergi Adı: JOURNAL OF CONTROLLED RELEASE
  • Sayfa Sayısı: ss.368-373

Özet

In this study, clobetasol-17-propionate (CP) loaded lecithin/chitosan nanoparticles were studied with special attention to the transport of the active agent across the skin in vitro. Nanoparticles were characterized by measuring particle size, zeta potential, polydispersity index and encapsulation efficiency. The morphology of nanoparticles was evaluated by transmission electron microscopy.