Behaviour of 9-Ethyl-9H-carbazole Hydrazone Derivatives Against Oxidant Systems: Protective Effect on Amyloid beta-Induced Damage


Karaaslan C., Ince E. , Gurer-Orhan H. , Tavakkoli M., Firuzi O., Saso L., ...Daha Fazla

CROATICA CHEMICA ACTA, cilt.92, ss.87-94, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 92 Konu: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5562/cca3481
  • Dergi Adı: CROATICA CHEMICA ACTA
  • Sayfa Sayıları: ss.87-94

Özet

Antioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this article, 9-ethyl-9H-carbazole hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity and possible cytotoxic effects were investigated. Furthermore, protective effect of the synthesized derivatives against amyloid beta-induced damage in PC12 neuronal cells was examined by using MIT assay. The newly synthesized carbazoles were found to have radical scavenging activity with a varying potency both in cell-free and cell-based in vitro assays. Several compounds, especially such as 3d and 3e, 3m and 3n bearing two halogen groups on the phenyl ring, were found to have cytotoxic activity. However, their cytotoxic activities were not higher than that of melatonin. Several compounds also significantly protected neuronal PC12 cells against amyloid beta-induced damage, which can be defined as neuroprotective agents. (4-(2-((9-Ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)benzonitrile) 3r was found as the most active compound with both radical scavenging activity and neuroprotective effects against amyloid beta-induced damage. These findings might provide an alternative strategy for developing novel carbazole derivatives for management of neurodegenerative diseases, such as Alzheimer's disease.