Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids


Oner E., Kotmakçı M. , Baird A., Gray S. G. , Debeleç Bütüner B. , Bozkurt E., ...More

JOURNAL OF NANOBIOTECHNOLOGY, vol.19, no.1, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 1
  • Publication Date: 2021
  • Doi Number: 10.1186/s12951-021-00781-z
  • Title of Journal : JOURNAL OF NANOBIOTECHNOLOGY

Abstract

Background: siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, and effective carriers are needed.