Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing enterocolitis

Erguen, MUSTAFA; ERGUEN, Gueliz; OEKTEM, Guelperi; SELVI, NUR; DOGAN, Hakan; TUNCYUEREK, Muege; SAYDAM, Gueray; ERDENER, Ata

doi:10.1016/j.jpedsurg.2007.05.024

Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing enterocolitis

Atıf İçin Kopyala

Erguen O. , ERGUEN G., OEKTEM G., SELVI N. , DOGAN H., TUNCYUEREK M., et al.

JOURNAL OF PEDIATRIC SURGERY, cilt.42, ss.1687-1694, 2007 (SCI İndekslerine Giren Dergi)

Cilt numarası: 42 Konu: 10
Basım Tarihi: 2007
Doi Numarası: 10.1016/j.jpedsurg.2007.05.024
Dergi Adı: JOURNAL OF PEDIATRIC SURGERY
Sayfa Sayısı: ss.1687-1694

Özet

Background/Purpose: The release of various enzymes including inducible nitric oxide synthase (iNOS) leads to enterocyte apoptosis through free nitrogen radicals, which in turn leads to impaired mucosal barrier and bacterial translocation with resultant sepsis in necrotizing enterocolitis (NEC). Resveratrol, a polyphenol compound from phytoalexins with antioxidant and scavenger properties, also play a critical role in modulating key enzymes in cell cycle including iNOS. We therefore hypothesized that resveratrol would prevent mucosal damage in experimental NEC in rats.