Clostridial collagenase aggravates the systemic inflammatory response in rats with partial-thickness burns

DÖKÜMCÜ Z. , Ergun O. , CELIK H. , AYDEMIR S., SEZAK M. , OZOK G., ...Daha Fazla

BURNS, cilt.34, ss.935-941, 2008 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 34 Konu: 7
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.burns.2008.01.001
  • Dergi Adı: BURNS
  • Sayfa Sayıları: ss.935-941


Aim: Clostridial collagenase A (CCA) has been shown effective in degrading collagen in eschar tissue and promoting healing in partial-thickness burns. As there are also reports of fever, leukocytosis, increased C-reactive protein (CRP) levels and septic complications during treatment with CCA, we aimed to determine in rats whether CCA aggravates the systemic inflammatory response.