Mulberry silk is one of the well known silk types. Especially, its lustrous appearance and handle properties make this fiber type an important natural source for textiles. Even if its properties let the fiber to be produced by itself, blending with other fiber types can be preferred in order to reduce raw material costs and make it more affordable. Cotton can be a good companion to this fiber type because of its tendency to be textile material. In this study, mulberry silk/combed cotton blended yarns were produced by using siro and ring spinning systems, in three different yarn counts. These yarns were dyed and then knitted in a laboratory type circular knitting machine. The comfort properties of these fabrics were investigated. According to test results, increasing silk content in the blend and using the siro spinning system positively affected the comfort properties of fabrics, in general.