Lower HbA1c targets are associated with better metabolic control

Van Loocke M., Battelino T., Tittel S. R. , Prahalad P., Goksen D. , Davis E., ...More

EUROPEAN JOURNAL OF PEDIATRICS, vol.180, pp.1513-1520, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 180
  • Publication Date: 2021
  • Doi Number: 10.1007/s00431-020-03891-2
  • Page Numbers: pp.1513-1520


Previous studies have suggested that clear HbA1c target setting by the diabetes team is associated with HbA1c outcomes in adolescents. The aim of this study was to evaluate whether this finding is consistent in a larger cohort of children from centers participating in the SWEET international diabetes registry. A questionnaire was sent out to 76 SWEET centers, of which responses from 53 pediatric centers were included (70%). Descriptive outcomes were presented as median with lower and upper quartile. The association between the centers' target HbA1c and mean outcome HbA1c was calculated using linear regression adjusted for age, diabetes duration, sex, and gross domestic product. Median age of the children in the studied centers (n = 35,483) was 13.3 [12.6-14.6] years (49% female). Of the 53 centers, 13.2% reported an HbA1c target between 6.0 and 6.5%, 32.1% had a target between >= 6.0 and 7.0%, 18.9% between >= 7.0 and 7.5%, and 3.8% between >= 7.5 and 8.5%. No specific target value was reported by 32.1% of all centers. Median HbA1c across all centers was 7.9 [7.6-8.3] %. Adjusted regression analysis showed a positive association between HbA1c outcome and target HbA1c (p = 0.005).