Chemical constituents and in vitro biological activities of Eremurus spectabilis leaves


Karakaya L., Akgül Y. , Nalbantsoy A.

NATURAL PRODUCT RESEARCH, vol.31, pp.1786-1791, 2017 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 31
  • Publication Date: 2017
  • Doi Number: 10.1080/14786419.2017.1292268
  • Title of Journal : NATURAL PRODUCT RESEARCH
  • Page Numbers: pp.1786-1791
  • Keywords: Eremurus spectabilis, Isolated compounds, Cytotoxicity and iNOS activities, ANTIOXIDANT ACTIVITY, ISOORIENTIN

Abstract

In the present study, phytochemical investigation of the young leaves of Eremurus spectabilis let to the isolation six compounds (1-6). Their structure was determined by spectroscopic analysis and comparison with the literature data. All compounds were isolated for the first time from E. spectabilis. Isolated compounds and prepared extracts did not show cytotoxic activity against HeLa (Human cervix adenocarcinoma), A-549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma), mPANC96 (Human pancreas adenocarcinoma), U87MG (Glioblastoma), PC3 (Prostate), CaCo-2 (Colon), HEK293 (Human embryonic kidney cells) cell lines. RAW 264.7 (murine macrophage cell lines) was used to determine the inhibition levels of inducible nitric oxide synthase (iNOS).The hexane extract was found to be active in terms of inhibition of iNOS (IC50: 25g/ml).