ELECTROCHEMICAL DNA SENSOR TECHNOLOGY FOR MONITORING OF DRUG-DNA INTERACTIONS


Erdem A. , KARADENİZ H. , Caliskan A. , Vaseashta A.

NANO, vol.3, no.4, pp.229-232, 2008 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 3 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1142/s1793292008001064
  • Title of Journal : NANO
  • Page Numbers: pp.229-232

Abstract

The objective of this investigation is to understand the nature and dynamics of binding small molecules to bio-macromolecules using electrochemical methods. The investigation pertaining to the design of site- and conformation-specific reagents provides a rationale for new studies of drug delivery design. Some anticancer drugs and DNA interactions have been undertaken by using a variety of techniques. Determination of interaction between DNA and DNA-targeted molecules would be valuable in the design of molecule-specific electrochemical biosensors for applications in diagnostics, development of drugs for chemotherapy, and as a biotechnological tool for DNA-based point-of-care diagnosis.