Contrasting effects of ATP and adenosine on capsaicin challenge in asthmatic patients

Basoglu O. K. , Pelleg A., Kharitonov S. A. , Barnes P. J.

PULMONARY PHARMACOLOGY & THERAPEUTICS, cilt.45, ss.13-18, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 45
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.pupt.2017.04.004
  • Dergi Adı: PULMONARY PHARMACOLOGY & THERAPEUTICS
  • Sayfa Sayıları: ss.13-18

Özet

Background: Adenosine 5'-triphosphate (ATP) stimulates pulmonary vagal slow conducting C-fibres and fast conducting A delta-fibres with rapidly adapting receptors (RARs). Pulmonary C-fibres but not RARs are also sensitive to capsaicin, a potent tussigenic agent in humans. Thus, the aim of this study was to determine the effects of ATP and its metabolite adenosine (given as adenosine 5'-monophosphate, AMP) on capsaicin challenge in asthmatic patients.