Experimental studies on animal models are necessary for the maintanence of practice and experience on IVF and ET, before starting an IVF program. Only so the handling skill of gametes zygote and human embryo culture can be improved. We have started for this reason with IVF on mouse occytes of CB6F1 Han hybrid strains and used modificated Ham's F-10 with 0.75BSA as culture medium. Until December 1988, 3652 oocytes were collected by the superouvulation of 178 oocyt donor mice. The fertilization rate was 67.94%. After the transfer of 62 hybrid embryos obtained from 4 other oocyt donor mice to 4 Balb/c recipient females, 1 recipient mouse delivered 10 living hybrid mice.