Use of Non-steroidal Anti-inflammatory Drugs for Chemoprevention of Inflammation-induced Prostate Cancer


DEBELEÇ BÜTÜNER B. , ÖZTÜRK M. B.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.14, ss.274-279, 2017 (ESCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 14 Konu: 3
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjps.41636
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Sayfa Sayıları: ss.274-279

Özet

Objectives: Chronic inflammation has been known as one of the major causes of cancer progression and 25% of cancer cases initiate due to chronic inflammation according to epidemiologic data. It has been determined that chronic inflammation induces carcinogenesis through the abrogation of cell proliferation, apoptosis, and angiogenesis mechanisms. Therefore, it is believed that inhibition of inflammation-induced carcinogenic mechanisms is an efficient therapeutic strategy in drug development studies of cancer chemoprevention. It has also been observed that use of anti-inflammatory drugs reduces the incidence of cancer, and the risk of developing prostate cancer decreases 15-20% with regular use of aspirin and non-steroidal anti-inflammatory drugs (NSAID).