Tideglusib protects neural stem cells against NMDA receptor overactivation


Armagan G. , Keser A. , Atalayin C. , Dağcı T.

PHARMACOLOGICAL REPORTS, vol.67, pp.823-831, 2015 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2015
  • Doi Number: 10.1016/j.pharep.2015.01.007
  • Title of Journal : PHARMACOLOGICAL REPORTS
  • Page Numbers: pp.823-831

Abstract

Background: N-methyl-D-aspartate (NMDA) receptors are major pharmacological targets to prevent or reduce the progression of neurodegenerative diseases. Successful therapy with NMDA receptor antagonists in humans has been limited by the severe side effects of complete receptor blockade. The aim of the present study was to investigate the possible protective effects of tideglusib against NMDA receptor overactivation in neural stem cells.