Tideglusib protects neural stem cells against NMDA receptor overactivation


Armagan G. , Keser A. , Atalayin C. , Dağcı T.

PHARMACOLOGICAL REPORTS, cilt.67, ss.823-831, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 67
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.pharep.2015.01.007
  • Dergi Adı: PHARMACOLOGICAL REPORTS
  • Sayfa Sayıları: ss.823-831

Özet

Background: N-methyl-D-aspartate (NMDA) receptors are major pharmacological targets to prevent or reduce the progression of neurodegenerative diseases. Successful therapy with NMDA receptor antagonists in humans has been limited by the severe side effects of complete receptor blockade. The aim of the present study was to investigate the possible protective effects of tideglusib against NMDA receptor overactivation in neural stem cells.