Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?


COKER A. , ÇOKER I., HUSEYİNOV A. , SOKMEN S., KARADEMİR S.

HEPATO-GASTROENTEROLOGY, vol.48, no.40, pp.1134-1137, 2001 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 40
  • Publication Date: 2001
  • Title of Journal : HEPATO-GASTROENTEROLOGY
  • Page Numbers: pp.1134-1137

Abstract

Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.