Is mannitol effective against platelet-activating factor (PAF)-induced liver damage in obstructive jaundice?


COKER A. , ÇOKER I., HUSEYİNOV A. , SOKMEN S., KARADEMİR S.

HEPATO-GASTROENTEROLOGY, cilt.48, ss.1134-1137, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 48 Konu: 40
  • Basım Tarihi: 2001
  • Dergi Adı: HEPATO-GASTROENTEROLOGY
  • Sayfa Sayıları: ss.1134-1137

Özet

Background/Aims: Platelet-activating factor, is a unique phospholipid with a broad range of biological activities that may be relevant in the development of inflammatory reactions. Platelet-activating factor has been suspected to play an important role in liver pathophysiology. The cultured Kupffer and endothelial cells produce and release platelet-activating factor in order to facilitate communication between hepatic sinusoidal and parenchymal cells. In this study, in the experimental jaundice model, platelet-activating factor levels were measured in liver tissue and plasma and the possible effects of mannitol on this mediator were assessed.